tag:blogger.com,1999:blog-12614519.post8603465532351007018..comments2024-03-28T09:37:33.796+10:00Comments on Opinion Dominion: I'll take it up when they can get it down to 45 secondsStevehttp://www.blogger.com/profile/04108945551064939734noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-12614519.post-86126089588561390102016-05-02T14:36:20.168+10:002016-05-02T14:36:20.168+10:00Yeah but as I just emailed to some friends ...
...Yeah but as I just emailed to some friends ... <br /><br /><br /><br /><br />So I decided to do my weekly email shredding and first opened the Mercola email because I enjoy shredding his emails but I found a lengthy article on the value of temperature changes. Thus ... <br /><br /><br /><br /><br />"[A]nimal studies have shown that when mice are exposed to the sauna they increase their protein synthesis by 30 percent compared to the mice that are not being exposed to the sauna. <br /><br />This was shown to be dependent on the heat shock proteins, HSPs, in the muscle. [T]he important thing here is the actual heat stress. You want to feel uncomfortable. You want to feel hot. That's when you know that these good pathways are getting activated. <br />---<br />Oh Look! My old friend heat shock proteins. I also had a suspicion that saunas would promote nitric oxide production via skin vasodilation because it is known that sunlight exposure can promote that as there are nitrate\nitrite stores under the skin and there are studies highlighting how that NO generation enters into systemic circulation. Note however NO has a short half life(30 sec) and spreads rapidly. Sure enough ... <br /><br /><br />See comment in PubMed Commons below<br />Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H548-54. doi: 10.1152/ajpheart.00103.2011. Epub 2011 May 27.<br /><br />Repeated sauna therapy attenuates ventricular remodeling after myocardial infarction in rats by increasing coronary vascularity of noninfarcted myocardium.<br /><br /><br />PMID:<br /><br />21622828<br /><br /><br />Circ J. 2006 Apr;70(4):463-70.<br /><br />Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia.<br /><br />16565566<br /><br />[PubMed - indexed for MEDLINE] <br /><br /><br />Free full text<br /><br /><br />Indeed "heat" shock is the basis for the term "heat shock protein", but it can also be produced by COLD shock. Hence maybe the value of Russians or Finns running from sauna to plunge into snow banks and roll around in them. <br /><br /><br />Yes, rapid temperature change induces greater heat shock protein expression and vascular dynamics. The HSP - amyloid clearance is obvious because various hsps bind unwanted proteins. I was thinking of this last night and it occurred to me that there must be a relationship between hsp expression to ubiquitination(where proteins are tagged for destruction). Interesting to see if temperature changes impact on ubiquitination. <br /><br /><br /><br />Even more speculatively, the rapid and large changes in vasculature dilation may promote dislodging of accretion from the endothelial walls and simultaneously promote the transport to the liver and kidneys for degradation and elimination(cold drives blood to the organs). <br /><br /><br />1) Erickson's data on benefits of brisk lengthy walking. Others speak of "exercise vigorous enough to MAKE YOU SWEAT".<br /><br /><br />I recall some studies which indicate sweat + sunlight is important for inducing nitric oxide production.Johnhttps://www.blogger.com/profile/17401232760394588049noreply@blogger.comtag:blogger.com,1999:blog-12614519.post-87965616360564157732016-05-02T13:25:00.323+10:002016-05-02T13:25:00.323+10:00Really? The problem is, I don't really like s...Really? The problem is, I don't really like sweating. :)<br /><br />I do enjoy Japanese onsen, though, although I do tend to go for the cooler for the coolest hot bath I can find.Stevehttps://www.blogger.com/profile/04108945551064939734noreply@blogger.comtag:blogger.com,1999:blog-12614519.post-90320099129570901112016-05-02T13:18:57.638+10:002016-05-02T13:18:57.638+10:00Since you don't like exercise try saunas. I lo...Since you don't like exercise try saunas. I looked into this a few years ago and follow up some studies last night. There are considerable health benefits to saunas. Johnhttps://www.blogger.com/profile/17401232760394588049noreply@blogger.comtag:blogger.com,1999:blog-12614519.post-28571820907225990702016-04-30T14:17:09.640+10:002016-04-30T14:17:09.640+10:001 minute is pushing the credibility too much. I ha...1 minute is pushing the credibility too much. I have long argued that most people spend far too much time exercising. Short intense workouts do appear better but more in the 10-15 minute range. The key issue is inducing a hormetic response. The problem with high intensity is that there is a higher risk of injury. Moreover my generic complaint with so much health advice is that it presumes a remarkable degree of homogeneity in human physiology. Johnhttps://www.blogger.com/profile/17401232760394588049noreply@blogger.com