Vaccination in history

I didn't know about the controversy over smallpox vaccination in its earliest days in England.   Mind you, it sounds like the anti compulsory vaxxers had something to worry about, given the technique:

In 19th century Britain, the only vaccine widely available to the public was against smallpox. Vaccination involved making a series of deep cuts to the arm of the child into which the doctor would insert matter from the wound of a previously vaccinated child.
These open wounds left many children vulnerable to infections, blood poisoning and gangrene. Parents and anti-vaccination campaigners alike described the gruesome scenes that often accompanied the procedure, like this example from the Royal Cornwall Gazette from December 1886:

Some of these poor infants have been borne of pillows for weeks, decaying alive before death ended their sufferings.