Three parent cellular fiddling a bad idea

A slippery slope to human germline modification

I've been meaning to post about the amazing lack of detailed media attention on the strange decision of the UK government to move ahead with trial of "three parent babies", by which parents who can tell they may well have babies with serious mitochondrial disease could create (with any luck) a healthy baby by completely mucking around with the insides of human egg cells.

This immediately struck me as absurd.  

Here's a simple solution, folks:   if you stand an extremely high risk of passing on serious and crippling diseases to your own genetic children - don't make your own genetic children!

Furthermore, there has been ongoing controversy for years as to the effects on IQ of test tube babies made using sperm injection.  Here's a 2005 story saying it has no effect.  Here's a 2013 story saying it does.  As well as a greater risk of autism.

OK, then.  Let's go on to not just inject a sperm cell, but rip out the nucleus of one woman's egg and insert DNA from another woman and see how that goes!

Isn't it pretty bleeding obvious that if the very mechanics of merely helping a sperm cell get into an egg increases risks significantly, it's extremely likely that the "three parent baby" process could only be worse in comparison?

Anyway, finally I see a article in a science journal (linked at the top, and in Nature, no less) in which someone makes the case against it.   After explaining this is to help a small number of women who have the problem, the article goes on to explain that even the process used to encourage approval for further trials is dubious:

Although proof of safety is, by definition, impossible in this situation, the evidence submitted up to now on mitochondrial replacement is far from reassuring. Most of the work has been on early-stage embryos; basic research on epigenetic and other interactions among nuclear and mitochondrial genes is lacking; animal studies are preliminary. The HFEA, which had originally asked that the mitochondrial-replacement technique being developed in the United Kingdom, called pro-nuclear transfer, be tested in non-human primates, later dropped that requirement — after US researchers found the technique to be unsuccessful in macaques.

Those opposed to green-lighting mitochondrial replacement have been described in some quarters as religious objectors, against all types of IVF. In fact, many secular and actively pro-choice scientists, bioethicists and women’s-health advocates have voiced grave and detailed concerns about the safety and utility of mitochondrial replacement, and about authorizing the intentional genetic modification of children and their descendants.

The HFEA, for its part, has made questionable claims of favourable public opinion about mitochondrial replacement. In 2012, the agency carried out a public consultation, which it said found “broad support” for the technique. Yet the consultation report shows something quite different. Of more than 1,800 respondents to the largest and only publicly open portion of the exercise (the element that in past consultations has been presented as the most significant), a majority opposed mitochondrial replacement.

The HFEA points out that the consultation included other “strands”: workshops of 30 people each; a public-opinion survey; two meetings with preselected speakers; and a six-person patient focus group. The sentiment in these strands tended to be more favourable, but this sentiment was encouraged in various ways. When a reference to a study caused uncertainty and concern, for example, it was dropped from subsequent discussions on the grounds that it was not relevant. The report noted that “some participants’ trust in the safety of these techniques is relatively fragile, and easily disrupted by new information”.

I feel entirely vindicated in my initial gut reaction.

Pointless article recommended

Farhad Manjoo, apart from possibility having the hardest journalist name in the world to remember how to spell without looking at it, sometimes writes entertainingly on technology at Slate.

And then, at other times, he's spectacularly trivial.  (No one could forget his jihad against double spacing after periods.)

His latest article, criticising Android phones because they usually include software you don't actually want (oh, and the excruciatingly long time - actually, it sounds like about 10 minutes - it takes to set up a new Android phone) is a good example of one of his poor excuses for a column.

Such pathetic justification for calling a phone "crap" (as compared to an iPhone) has, as you might expect, puzzled some people in comments following:

 This column appears to be a complaint in search of a problem. First, there's nothing remotely unusual, as stated in the first paragraph, about Google making an OS and leaving it up to manufacturers to design devices for it. Microsoft has dominated the PC industry since the 1980's by taking the exact same approach. Likewise, there's nothing inherently better about a device that's "exactly how Apple wants it" as opposed to how some other company wants it. Either way, the device isn't exactly how the user wants it -- and in the case of Apple, there isn't any other way the user can get it either.

And:

I'm an Apple user for a number of reasons, but the "crapware" argument doesn't hold much water for me, given that Apple loads the iPhone with "GameCenter," "NewsStand," "Passbook," "Stocks," not to mention the execrable "Maps," which, while not exactly ads, certainly are crap that I definitely don't need, and that I CAN'T DELETE AT ALL, unless I void the warranty and hack the phone.

The sarcasm is starting to build when you reach this comment: 

Yeah, I hate powerful, inexpensive phones that can easily move proprietary carrier software to the background or root to a base version of the OS. The universal charging port, free apps, open source coding and competitive hardware market just make it worse.
 
Give me an overpriced phone from a price-fixing bully of a company that's outdated on its release and designed for hipsters and the technologically illiterate. How else will I map my drive from an island that doesn't exist to a national park that's in the wrong state?

And gets a bit personal further down:

Farhad's objections aside, I would rather live in the universe of Samsung than the hideous dead world of Apple, with its fetid and rank odor of pancreatic cancer and denial and "All phones must be small" and everything else that I find offensive with that bizarro corporate worldview. Thank god for Samsung, hey? Tomorrow, maybe I'll root again, but seriously I find myself unhampered by what I'm living in now.

I don't have a smartphone of any description, although the cheapie one my wife uses seems perfectly adequate to me.  In the matter of comparing iPads to Android tablets I have firmer views, which I should one day express is a post.  Well I would, except for the fact that my firm view is that neither  one knocks the other out of the ballpark. 

What to think of the Ruddy climate?

John Quiggin � The return of the ETS

The whole issue of carbon pricing via emissions trading schemes and/or carbon taxes has always been very complicated, and I generally used to tend to doubt the wisdom of the former.

And given that the European scheme is a bit of a mess that may or may not be capable of being fixed,  the Kevin Rudd policy of moving to a floating price ETS a year ahead of schedule seemed something very hard to judge.

I therefore had to outsource opinion on this to John Quiggin, and as he does not seem particularly perturbed, perhaps I should not be either.  

The age cohort of Catallaxy participants speaks....

(I noticed today a large number of people at Catallaxy self identifying as being well over the half century.  Older, but not wiser.   Amongst other great highlights there lately, a bunch of men,  over 60 mostly I suspect, puzzling about why, oh why, do skeptic associations tend to believe in AGW, you know, as if it is real.   Clueless.)

Back soon....

Things to be done, and fun using Pixlr (for on line image editting, and then Superlame to add voice ballons, as well as Irfanview to do a resize for my blog width) is too distracting.

Back in a few days, I think....

Quite a gap

BBC News - Class divide in boys' reading skills seen in Pisa scores

The brightest boys from poor homes in England and Scotland are at least two-and-a-half years behind in reading compared with those from the richest homes, a study suggests.

Research for the Sutton Trust educational charity says Scotland's gap is the highest in the developed world, while England's is the second highest.

In Finland, Denmark, Germany and Canada, the gap is equal to 15 months.
The government in England says its reforms will improve reading standards.

Clever Brian

I'm not the biggest fan of physicist Brian Cox as a media personality - he looks just a little too happy all the time.  But last night, the first time I saw an episode of his Wonders of Life series (which is sort of a David Attenborough meets physics show), I was quite impressed by this sequence:

Not exactly looking like something da Vinci had in mind

Canadian Team Claims $250,000 Prize for Human-Powered Helicopter | Autopia | Wired.com

At the link, there's a video of a human powered "helicopter", of odd design.  It sort of looks fake at first, but it isn't.  Still,  they won a prize, so congratulations are due.

Tony takes up the fight

  

I had an earlier version up for a while, but have made some further changes.   I trust that my Friend from Perth reports to a certain blog that I finally found a way to post an image of a nude Abbott.  

My one man Jihad against Tony continues...

Pleasing movie news

James Bond: Sam Mendes directs Skyfall follow up

I wonder if they will allow James to be a little bit happier this time around.  

Bad news Friday, Part 2

Energy production causes big US earthquakes : Nature News 

Natural-gas extraction, geothermal-energy production and other activities that inject fluid underground have caused numerous earthquakes in the United States, scientists report today in a trio of papers in Science^1–3.

Most of these quakes have been small, but some have exceeded magnitude 5.0. They include a magnitude-5.6 event that hit Oklahoma on 6 November 2011, damaging 14 homes and injuring two people, says William Ellsworth, a seismologist at the US Geological Survey in Menlo Park, California, and the author of one of the papers¹.

He says that the annual number of earthquakes record at magnitude 3.0 or higher in the central and eastern United States has increased almost tenfold in the past decade — from an average of 21 per year between 1967 and 2000 to a maximum of 188 in 2011. A second study², led by Nicholas van der Elst, a seismologist at Columbia University's Lamont-Doherty Earth Observatory in Palisades, New York, finds that at least half of the magnitude-4.5 or larger earthquakes that have struck the interior United States in the past decade have occurred near injection-well sites.

Bad news Friday

A blog at the Guardian notes that there is a new James Hansen led paper out soon that argues that burning all our fossil fuels could effectively ruin the planet for humans (too hot to grow food grains, for example).  The concern is about poorly understood feedbacks that may lead to a mini runaway increase in temperatures.

That's a worry, of course, but I was more interested to read a summary of other recent papers arguing that there are grounds to question whether a 2 degree increase in global temperatures is really a "safe" level.   I've always thought that there was probably a lot of guesswork in that nominal figure, and it is important if it is too "conservative", especially as there has been much publicity lately that the sensitivity to doubling CO2 is closer to 2 degrees than to 3 or 4.   If the sense of complacency that some are encouraging as a result of that is ill founded, we should know. 

Anyway, here's the summary:

The new paper by James Hansen is just the latest confirming that we are on the verge of crossing a tipping point into catastrophic climate change. Other recent scientific studies show that the current global emissions trajectory could within three years guarantee a 2C rise in global temperatures, in turn triggering irreversible and dangerous amplifying feedbacks.

According to a scientific paper given at the Geological Society of London last month, climate records from Siberian caves show that temperatures of just 1.5C generate "a tipping point for continuous permafrost to start thawing", according to lead author Prof Anton Vaks from Oxford University's Department of Earth Sciences. Conventional climate models suggest that 1.5C is just 10-30 years away.

Permafrost thawing releases sub-ice undersea methane into the atmosphere - a greenhouse gas twenty times more potent that carbon dioxide. In June, NASA's new five-year programme to study the Arctic carbon cycle, Carbon in Arctic Reservoirs Vulnerability Experiment (CARVE), declared:

"If just one percent of the permafrost carbon released over a short time period is methane, it will have the same greenhouse impact as the 99 percent that is released as carbon dioxide."

Another paper suggests that conventional climate modelling is too conservative due to not accounting for complex risks and feedbacks within and between ecosystems. The paper published in Nature last Wednesday finds that models used to justify the 2C target as a 'safe' limit focus only on temperature rise and fail to account for impacts on the wider climate system such as sea level rise, ocean acidification, and loss of carbon from soils. It concludes that the 2C target is insufficient to avoid dangerous climate change.

Abbott's anxiety rise continues...

I've just been watching Kevin Rudd's Press Club address on the economy.

He sounds confident, across a lot of details, consultative and smart.   Less "Ruddisms" in expression too.

There is no doubt he has been improved greatly by being dumped.

He makes, more than ever, Tony Abbott sound like a mere shallow sloganeer.  

(And I'll make another call out across the interwebs:  cry Catallaxians, cry...)

More "you don't say...."

Combination of smoking and heavy drinking 'speeds up cognitive decline'

Mind you, seems to me the effect is not exactly all that pronounced:

The research team found that in current smokers who were also heavy drinkers, cognitive decline was 36% faster than in non-smoking moderate drinkers. This was equivalent to an age effect of 12 years – an additional two years over the 10-year follow up period. 

Is it that easy to tell the difference between, say, a 67 year old brain and a 65 year old one?

 

You don't say....

Men and Women Often Expect Different Things When They Move In Together - W. Bradford Wilcox - The Atlantic

A study confirms what common sense and observation should have already made clear:

 According to a new paper from RAND by sociologists Michael Pollard and Kathleen Mullan Harris, cohabiting young adults have significantly lower levels of commitment than their married peers. This aversion to commitment is particularly prevalent among young men who live with their partners.

I wonder how many fathers point this out to their daughters?   I mean, they understand the likely psychology of men better than the mother.   

Brisbane colonial history noted

I was in the State Library bookshop last Sunday, killing a bit of time before heading off to see War Horse, and briefly noted a book (a novel, I think) which revolved around the Brisbane Bread Riot of 1866.

That's an event I didn't recall having heard about before, so I Googled it up.

I can't seem to link to it directly, but the first on the list should be the link to a good article by Paul Wilson explaining what it was about (basically, not enough work or food for immigrants arriving on boats expecting same, and the government being blamed for poor organisation.)

It has a couple of good, old photos of Brisbane in the period too.

Cities sure changed a lot in the century ranging from 1866 to 1966, didn't they?

Probably not a good idea to eat asparagus before using

Device can sniff out bladder cancer | News.com.au

Fighter pilot redundancy coming soon

US Navy drone lands on aircraft carrier deck in robotic flight breakthrough - ABC News

Something to look forward to?

The Joy of Old Age. (No Kidding.) - NYTimes.com

Oliver Sacks writes a short essay on how he is not at all depressed about reaching 80.  

We would all hope we can feel the same way.