Empathy in the news

There's a book out with the somewhat provocative title Against Empathy, and the author explains it at Vox, and lots of sites discuss his argument, such as at Psychology Today.

In a similar vein, you can read how Too Much Emotional Intelligence is a Bad Thing.

I should drink more

Tea, that is.

My hunch from articles that continually flow about the health benefits of certain drinks is that the healthy lifestyle might involve:   one strong cup of coffee per day; one cup of tea per day; one glass of red wine every second day.  And then I can stand on one of those silly looking vibrating boards instead of exercising, because, surprisingly, they might actually be good for you too.

In other movie news

Who can believe the US (and international) box office for Beauty and the Beast?  

Just goes to show, too, that the publicity about a gay "moment" in the film has caused no significant conservative backlash, at all.   (Anyway, I see that the "moment" is exceeding brief.)

Excuse me while I have a fanboy moment

Good to hear, but maybe this one shouldn't be at the start of the film:

....it sounds like Mission: Impossible 6 is going to have a stunt so insane that Cruise has been training to do it for over a year. That’s according to Collider, which spoke with M:I 6 producer David Ellison about the film.
According to Ellison, this new stunt is going to be “the most impressive and unbelievable thing that Tom Cruise has done in a movie,” and he’s been preparing for it since “right after Rogue Nation came out.” He wouldn’t offer any specifics, but he explained that Cruise prefers doing real stunts like this because “the audience can tell when it’s you on a green screen or when you’re actually doing it live.”

Take that, Thiel

Oh.  Isn't one of Peter Thiel's policy ideas that the drug market should be opened up so that people can try them out before they go through all of the expensive testing?

Well, here's a short argument at Nature that there are good economic (and social) reasons to insist that drug companies show efficacy before they release drugs.  Some extracts:

Knowledge of the history is important. The 1938 US Food, Drug, and Cosmetic Act required only that drug safety be demonstrated. In 1962, new legislation demanded that marketed drugs also go through well-controlled studies to test for therapeutic benefit. More than 1,000 medical products were subsequently withdrawn after reviews found little or no evidence of efficacy¹. The free market that existed before 1962 revealed no connection between a drug's ability to turn a profit and its clinical usefulness. The same is likely to be true of any future deregulated market....

An overly stringent system will err by withholding or delaying safe and effective 'good' drugs from patients. Critics of existing regulations often point to the case of a treatment for Hunter syndrome — a rare, inherited degenerative disease in which the absence of a crucial enzyme can be fatal. Trials of the enzyme-replacement drug Elaprase (idursulfase) meant that, for a year, a group of children received a placebo instead of the drug that was eventually shown to be effective².

Conversely, a lax regulatory system will subject patients to 'bad' drugs that may be toxic. The iconic example is the more than 10,000 birth defects caused worldwide by the drug thalidomide, a late 1950s remedy for nausea during pregnancy. Even in the past dozen years, initially promising drugs, such as torcetrapib (for reducing cholesterol and heart-disease risk) and semagacestat (for improving cognition in people with Alzheimer's disease), were found to cause harm only after they had been tested in large, mandatory trials — effects that were not seen in the smaller trials³.

The most extreme proponents of deregulation argue that the market can serve as the sole arbiter of utility: if a medicine is selling well, it must be delivering value⁴. A more moderate view is that reliable information on efficacy can be collected after a drug goes on sale, through uncontrolled observational studies and other post hoc analyses.

There is a third type of error that these arguments neglect (see ‘The good, the bad and the useless’). Untested drugs can be reasonably safe but provide no benefit.

And here's the key point:

Arguments for deregulation fail to recognize that valuable information has a cost. Drug companies cannot afford to generate reliable evidence for efficacy unless their competitors are all held to the same high standards. Efficacy requirements level the playing field and ensure that the health sector receives the data needed to inform good therapeutic and economic decisions. The government, insurers, patients and others need to know whether medicines are likely to provide benefits. Patients and physicians must have access to reliable information to make educated and ethical choices.

Rigorous clinical studies are still the best way to learn whether a drug works, and regulation is essential to ensure that these studies are conducted. Pre-specified endpoints, controls, randomization and blinding cannot be discarded without sacrificing actionable clinical information⁵.

Once a drug is on the market, it is hard to gather solid efficacy data....

The FDA's gatekeeper role makes the medical marketplace function. The economic benefits of good research and a healthier population will be lost without incentives to find truly effective drugs.

Jason - that article is definitely tweet worthy, no?

Update:   I just Googled up an article at Vox from a couple of months ago that explained the pro FDA argument from a medical point of view.   A lot of this read like what John just said in comments:

Thiel, a libertarian iconoclast, has repeatedly made the case that the FDA gets in the way of drug innovation by making it too difficult for new medicines to get to the market. Some of the FDA candidates he’s identified — including Silicon Valley’s Jim O’Neill and Balaji Srinivasan — have similarly argued that the agency should dump its requirement that drugs be proven effective before reaching the market, and that we’d be better off if the FDA operated more like a “Yelp for drugs.” In other words, bringing the same speedy and disruptive approach to medical regulation that Silicon Valley brought to the taxi and hotel industries, for example, will unlock cures — fast. 

But Thiel and his pals miss a very important point about developing new drugs: Manipulating biology isn’t the same as manipulating computer code. It’s much, much harder. Speeding up medical innovation will take a lot more than just stripping down the FDA — it’ll take huge leaps forward in our understanding of biochemistry and the body. Health care is also different from taxis and hotels in another key way: Consumers can’t really judge the safety and quality of medical products by themselves....

...I asked a longtime pharmaceutical scientist (and conservative), Derek Lowe, for his views. In his 28 years in the lab, Lowe has seen hundreds of thousands of compounds tested on a huge variety of drug targets, and never, not once, has he brought a drug to market.

The reason? “We don’t know how to find drugs that work,” he said.

For every 5,000 compounds discovered at this "preclinical" phase of drug development, only about five are promising enough to be tried in humans. That’s a success rate of 0.1 percent.

Drug innovation comes from painstaking tinkering and a dash of luck. “It’s very tempting for someone who has come out of IT to say, ‘DNA is code, and cells are the hardware; go in and debug it’,” Lowe said. “But this is wrong.”

In Silicon Valley, humans have designed the hardware, software, and computer code they’re working with. In medical research, scientists do not have that advantage, Lowe said. “We have 3 billion years of spaghetti-tangled gibberish to deal with. And unless you’ve done [drug development], it’s very hard to get across how hard it is. I don’t know of anything that’s harder.” Biochemistry and cell biology are “like alien nanotechnology,” he added.

So the real hurdle researchers face when it comes to finding new drugs for people isn’t overcoming a stringent regulator; it’s grappling with that “alien nanotechnology” in the lab.

Update 2:  from another article, talking about the effect of having an FDA that insists on showing efficacy as well as safety:

Pharmaceutical executives complain about the drug approval process, but usually don’t want to go anywhere close to a safety-only path. In practice, what they want is for the FDA to return their calls, for bureaucratic delays to be reduced, and to find the fastest and least expensive way to prove safety and efficacy.

Many biotech entrepreneurs are actually fans of a tough FDA. Pharmaceutical billionaire Leonard Schleifer, the founder and chief executive of Regeneron Pharmaceuticals, said that he was against “making it really easy to get your drug approved” at the Forbes Healthcare Summit last week, before news of that O’Neill was under consideration leaked.

Schleifer said that he couldn’t compete with companies like Pfizer or Eli Lilly, which have 10 to 100 times as many salespeople as Regeneron. But he can compete to get approved first, or to have a better drug that has more uses that the FDA allows it to advertise based on science.

“Having a high bar is a good thing, in my opinion, because it allows innovators to compete,” Schleifer said.

Krugman on infallibility

Heh.  Krugman writes:

This administration operates under the doctrine of Trumpal infallibility: Nothing the president says is wrong, whether it’s his false claim that he won the popular vote or his assertion that the historically low murder rate is at a record high. No error is ever admitted. And there is never anything to apologize for.

O.K., at this point it’s not news that the commander in chief of the world’s most powerful military is a man you wouldn’t trust to park your car or feed your cat. Thanks, Comey. But Mr. Trump’s pathological inability to accept responsibility is just the culmination of a trend. American politics — at least on one side of the aisle — is suffering from an epidemic of infallibility, of powerful people who never, ever admit to making a mistake.

Quite true, and use of "infallibility" perhaps explains the psychological position of Trump's conservative Catholic vote:  they have already spent decades defending and being intellectually and emotionally invested in Papal infallibility - so it's a ready made mindset in which to move into arguments that, at heart, Trump is never wrong.   

Slow news day

Yeah, sure, the weird situation in Washington continues, with the investigation into Trump's campaign ties to Russia continuing, and confirmation that Trump prefers to make his baseless claims from what Breitbart and Fox News tells him, rather than his intelligence community. 

But all sensible people had already realised this, so it doesn't feel new.

Of course, what it means for foreign governments dealing with him is anyone's guess - they know they're dealing with a gullible, emotionally needy (jeez, how long is going to continue holding rallies just to cheer himself up?) idiot, so what hope do they have of negotiating in good faith with him, or his administration?   His behaviour with Merkel made him look like a misogynist who especially can't conduct serious negotiations with a woman he doesn't agree with.

We nervously await his first serious test from a foreign power.

Meanwhile, in Australia, the Coalition federally keeps fretting about a terribly minor issue as far as the big picture goes - s18C of the Racial Discrimination Act.  And coming up with semi populist ideas that don't make any good sense (release superannuation to buy a house as an answer to the ridiculous house prices in Sydney and Melbourne.)

It all has the feeling of a government fiddling around the edges, casting about for ideas, and not really knowing where to find them.   

What about the one, big, unexpected one that went over well in the media last week - Turnbull's Snowy Mountain expansion?   I am not inclined to get too excited until the feasibility study comes in.  The last were done in the 1980's, apparently, and since then, I thought there was an issue with decreased precipitation likely due to climate change.  That's the first hurdle with any hydro scheme - enough water.  

Oh, here's something to amuse me - watching the build up to the release of the next Samsung phone.  OK, maybe it's a tad more pathetic than amusing, watching how companies and their PR staff go about trying to create intrigue and excitement over a product which is, in truth, probably only a marginal improvement over the last high end phone.  But really, it has been interesting watching the ad campaigns deployed by Samsung to overcome the fear of their exploding batteries.   And beside, I still love my tablet and my Samsung TV - I want this company to do well.

A bug you don't want

There's a fair bit I didn't know about the nasty MRSA (Staphylococcus) bacteria explained in this article from NPR.  

Back to the definition issue

I would have guessed that there was little to be added to the whole argument about the invention of "homosexual" as a category of person, given that it has been well publicised in recent decades. 

But this article at the BBC talks of the invention of "heterosexuality", which is a somewhat different take on the matter.  I thought it interesting, despite my low expectation from the title...

Not just me (again)

I see that Crikey has been keeping count of the extraordinary number of words The Australian has devoted to Bill Leak.

I guessed, in my last post about this, that Leak had been eulogised 49 times.  I was actually pretty close - I think it must be up to 44 now.  (Crikey cites 43, but there might be another one today.)

Surely Leak himself would be finding this over the top...

Spooky Spanish

Hey, finally I found a movie on Stan that I consider above a B grade.

It's the 2007 Spanish haunted house movie The Orphanage.

I had vaguely remembered that it had good reviews when released, and I see now that it scored 87% on the semi reliable Rottentomatoes.

I agree with most of the review extracts I can see at Rottentomatoes - it's frequently suspenseful, surprising, and so well crafted.     It's hard to describe the ending without giving anything away - but it hits with quite an emotional punch.

I think it's pretty rare to find a scare movie that is emotionally resonant - although, I must say, I think that that was the reason that Poltergeist was so successful.  You really did feel the emotion between the parents and the daughter in that film, too.  [And, I will add, that there is one sequence in the film which some might say is very derivative of Poltergeist - but I found it entirely forgiveable. In fact, now that I think of it, thematically  the movies are perhaps a bit similar in a more general sense, too.]

Identity disclosed

I was getting my daily dose of nonsense from looking at the Catallaxy open thread today, when I noticed that one of the regular thread presences, "memoryvault", mentioned having published 3 books, by title.

This made it easy to Google him, and it would appear that memoryvault is Peter Sawyer.  Maybe that's been disclosed there before* - it is not as if I read every single thread or comment, but this is new to me.

Now, there were hints previously (from the oddball commenter Fisk, I think) that  MV had been involved in nutty Right wing politics a few decades ago, and yes, I see that he is the subject of some material on the 'net.  I'm not sure of the author of this piece talking about far right politics in Australia in the 80's and 90's, but here's what he (or she) writes about Sawyer:

Soothsayers and false prophets made the message propagandistically immediate.  Peter Sawyer, a sacked Social Security employee, became an oracle.  Sawyer rose to fame upon insisting a conspiracy existed at the ‘Deakin Centre’ to use super-computer departmental linkages to re-formulate the ‘Australia Card’.[55]  In 1987 he predicted Aboriginal revolution:

The real weapons for the Great Black Revolution arrived quietly in WA some months ago.  7,000 AK47 Russian assault rifles, plus ammunition.  These were shipped in on false documents prepared by Fuller Firearm Group of … Sydney.  Transfer of funds was arranged through Mr. Laurie Connell’s Merchant Bank, Rothwells and they are currently …  stored … around various warehouses owned by Mr. Alan Bond.[56]

Panic was recorded in some rural centres.[57]  Sawyer drew large audiences in many Queensland towns[58] and was vociferously endorsed by Sydney radio personality Brian Wilshire, who subsequently authored ‘conspiratology’ books himself.[59]  Sawyer suggested black revolution was a plot of the United Nations to permit military intervention in Australia.

Sawyer’s wild tales utilized ex-CPA member Geoff McDonald, whose Red Over Black, described ‘Land Rights’ as a communist/United Nations conspiracy.[60]  ‘Pro-mining’ McDonald, who had been patronized by Bjelke-Petersen, Ruxton, the LOR and Liberal-National branches, travelled throughout Australia during 1979-85, predicting violence.[61]  Nonetheless, Sawyer’s star-gazing outdid  McDonald and even Eric Butler, who denounced him.[62]

Googling around further led me to a 2010 comment on an Andrew Bolt thread, where it would appear that Sawyer was doing a Trump - talking about himself without disclosing it:

 Memory vault

Yes, of course MV/Sawyer would have been an early climate change denier - in fact, denial of climate change is really the only thing that absolutely all threadsters on Catallaxy have in common now.   It is the one issue that they will never argue about, which shows what a sheltered home for the easily fooled it has become.

Anyway, I wonder how many of the old timers there are aware of the extraordinary wrong-ness of Sawyer's previous political warnings...

*  Update:  yes, it was disclosed before, by Sawyer on Catallaxy, back in 2015.  In fact, now that I read the disclosure in 2015, I think I had seen that before, but what I had never bothered doing was Googling his name to see what he was known for, politically.

Being a politician used to be a much tougher gig..

An article in this week's Science magazine starts:

Don't worry, you're almost certainly real (and so is everything else)

I've never been really taken with the idea that the universe is just a computer simulation running on some advanced intelligence's computer.   I don't know - just always seemed a bit redundant to argue that instead of looking at reality at every single level from quarks to galaxy clusters, we're looking at someone's super computer simulation that's good enough to make every single level from quarks to galaxy clusters look, feel and behave real. 

And I see that I'm in good company - physicist Bee at Backreaction has a ranty post complaining about the whole idea, too.   Here are some of her key paragraphs:

If you try to build the universe from classical bits, you won’t get quantum effects, so forget about this – it doesn’t work. This might be somebody’s universe, maybe, but not ours. You either have to overthrow quantum mechanics (good luck), or you have to use qubits.

Even from qubits, however, nobody’s been able to recover the presently accepted fundamental theories – general relativity and the standard model of particle physics. The best attempt to date is that by Xiao-Gang Wen and collaborators, but they are still far away from getting back general relativity. It’s not easy.

Indeed, there are good reasons to believe it’s not possible. The idea that our universe is discretized clashes with observations because it runs into conflict with special relativity. The effects of violating the symmetries of special relativity aren’t necessarily small and have been looked for – and nothing’s been found.

For the purpose of this present post, the details don’t actually matter all that much. What’s more important is that these difficulties of getting the physics right are rarely even mentioned when it comes to the simulation hypothesis. Instead there’s some fog about how the programmer could prevent simulated brains from ever noticing contradictions, for example contradictions between discretization and special relativity....

And this section made me smile:

Stephen Wolfram (from Wolfram research) recently told John Horgan that:

“[Maybe] down at the Planck scale we’d find a whole civilization that’s setting things up so our universe works the way it does.”

I cried a few tears over this.

The idea that the universe is self-similar and repeats on small scales – so that elementary particles are built of universes which again contain atoms and so on – seems to hold a great appeal for many. It’s another one of these nice ideas that work badly. Nobody’s ever been able to write down a consistent theory that achieves this – consistent both internally and with our observations. The best attempt I know of are limit cycles in theory space but to my knowledge that too doesn’t really work.

Again, however, the details don’t matter all that much – just take my word for it: It’s not easy to find a consistent theory for universes within atoms. What matters is the stunning display of ignorance – for not to mention arrogance –, demonstrated by the belief that for physics at the Planck scale anything goes. Hey, maybe there’s civilizations down there. Let’s make a TED talk about it next. For someone who, like me, actually works on Planck scale physics, this is pretty painful.

To be fair, in the interview, Wolfram also explains that he doesn’t believe in the simulation hypothesis, in the sense that there’s no programmer and no superior intelligence laughing at our attempts to pin down evidence for their existence. I get the impression he just likes the idea that the universe is a computer. (Note added: As a commenter points out, he likes the idea that the universe can be described as a computer.)

So put away your Matrix movie DVDs (I never really got past the first one anyway - it might have them that put me off the simulation idea.)  Go out and smell the (real) roses.

Rats -v- Mice

There are some charming descriptions of rats from medical researchers in this article explaining how they are becoming more popular as the preferred animal model (over mice) for certain research (autism is the one discussed in detail.)  For example:

In a shoebox-sized cage on their own floor in the Anderson Building at the Baylor College of Medicine, two little white mice with pink ears and skinny tails scurry over a bedding of corncob strips. They run from corner to corner, now and again standing on hind legs to press their paws against one of the cage’s clear plastic walls. Occasionally, they bump into each other and take a sniff. Mostly, they do their own thing.

On another floor of the same building, larger cages hold white rats that can’t seem to stay away from each other. They pounce, wrestle and roll. It’s impossible to avoid the comparison: They act like puppies.

“You can actually grab the rats and put them in your hand and treat them exactly how you would treat a puppy,” says Surabi Veeraragavan, a behavioral geneticist at Baylor in Houston, Texas. Regular handling, she says, helps rats get used to the scientists who study them. “You can put them on your shoulder, you can put them on your arms; they will go to sleep right away. You can pet them and play with them.”

Holding a rat can be like cradling a baby, adds Rodney Samaco, the molecular geneticist who leads the Baylor team. “They like to put their head in the crevice of your elbow,” he says. They practically purr. “You tickle their stomachs; they like that.”

“They love that!” says Veeraragavan.

The Baylor team also studies mice, which were there long before the rats and still outnumber them. But when Samaco and Veeraragavan talk about the lab’s mice, their words are less affectionate: The mice are less social, their behaviors simpler; they aren’t nearly as cute.

If you put a mouse on your arm, as you would a rat, it wouldn’t end well, says Samaco. “They would look very nervous,” he says. “Then, they would bite you.”

See - it's not just me who finds them cute...

Made me laugh

I was going to comment "surely Roxette are only 20 years old, tops." But no, formed in 1986 (!)

Comments on a Lady

My wife and I saw the Julie Andrews directed revival of My Fair Lady last night.

I had gone in with relatively low expectations - I said to my wife it was not really a favourite musical of mine - so I can say I enjoyed it more than I expected.    It is a pretty lavish looking production; all of the actors do very well; the orchestra seemed good, and has quite a lot of work (OK, maybe not as much as the poor musicians who have to do Les Mis); and while the lead actress does sound exactly like Julie Andrews, it didn't come across to me as a studied imitation.

That said, the first (very lengthy) half is more enjoyable than the angsty second half.

And the main issue anyone probably has with the show is one which is not really its fault - as with Pygmalion, its ending is not really satisfying, and it arrives rather abruptly.

If my memory of the play from high school is correct, Shaw added an explanation at the end that Eliza went on to marry dumb Freddy - but it is not part of the play.  Nor is it part of the musical.

Viewed through the modern eye, the ending has the feeling of a return to an abusive relationship - a problem I think we are more sensitised to now than when the play and musical were created.  Which had me thinking, how would a theatre playwright end this sort of story today?

Here's the best I could come up with, so far:  Henry Higgins turns out to be gay, and ends up marrying Colonial Pickering; perhaps with Eliza as the celebrant (her new found career.)    I mean, come on - this is hardly a stretch from all of the talk from Henry about great men are.  :)  And, in fact, thematically, it fits quite well into Shaw's point about morality having nothing to do with divinity, but is, rather, a mere social construct.

If Julie Andrews wants to create real waves with this production, she now knows how to do it.  (I have read that she is in fact in Brisbane, and I think will be at the official opening of the show on Sunday night.  Cool, we are blessed with royalty.)

Update:  interested readers might care to look at this article from The Telegraph, that discusses the issue of the ending of the play, and musical, in some detail.

Day 7, and The Australian's art department is ready for tomorrow's eulogy (number 49 in a series) on Bill Leak...

 

Controversy about the Pope, again (and I missed a conservative Catholic disclosure)

Pope Francis Sneaks Leftovers To False God Moloch At Back Door Of St. Peter’s Basilica

VATICAN CITY—Quickly scanning the alley to make sure no one would see him with the scraps he had placed on a spare offering plate, Pope Francis reportedly stepped out the back door of St. Peter’s Basilica late Wednesday night and slipped leftovers to the false god Moloch. “I know I should be forsaking him, but what am I supposed to do, let the poor thing starve?” said the pontiff, cooing in Aramaic as he fed uneaten portions of chicken casserole to the bull-headed Canaanite god of child sacrifice. “Maybe it’s heretical of me, but just look at the guy—he’s nothing but skin and bones and horns. If I don’t take care of him, who will?” Reached for comment, the heathen idol Moloch expressed appreciation for the leftovers, but confirmed he could only be fully satiated by consuming the flesh of a living man-child set forth in offering upon a burning pyre.

 From The Onion, but they might have lifted it from Church Militant.

Hey, speaking of Church Militant - I haven't looked at what the man with the hair, Michael Voris, had been up to for quite a while, but I just went and had a look at a Wikipedia page about him.  Turns out that nearly a year ago,  he declared he had lived with  gay guys during his 30's - and slept with women too.  But he's celibate now (he's never married), and he's devoted his chastity to the Blessed Virgin or something, so he's free to condemn homosexuality. 

I wonder if that disclosure has affected his subscriptions...

Update:   I had forgotten how strongly I had criticised Voris and his ilk back in 2013.   I always thought his "never married" status was a bit suspect - especially for a man with a Robert Redford hairstyle, but I was too polite to mention it back then.  

Move to Brisbane

The problem with government getting too involved in trying to push people to where government thinks they should live is that it rarely seems to work.   Decentralisation of government departments just irritates people, for example, despite a fondness for the idea by both Whitlam and (now) Barnaby Joyce.

But with all the talk of the extraordinarily high housing prices in Sydney and Melbourne, and the impossibility of young adults to get into the real estate market there without family help, it does seem to me that governments, or someone, should be putting more effort into emphasising the very high affordability of housing and units within a 45 min commute of Brisbane.   (Such a commute being nothing in the larger cities.)

Here is a photo of Raby Bay marina, at Cleveland, which is on Moreton Bay:

It has a string of decent restaurants, a bar or two, and is at the end of the train line which, admittedly, does seem to take a long time (1 hour 25 min) to get into the city compared to the car commute which Google puts down as low as 40 min.

But look, you can buy a two bedroom, two bathroom, one car apartment in this block for $319,000.  (!)

Or in Cleveland (the suburb Raby Bay is really part of) for $595,000 (list price) a four bedroom, modern airconditioned house:

Over on the west side of the city, and now near a rail line as well, at Forest Lake for "offers over $439,000":

Commute time to city:  25 minutes (outside of peak hour) and 24 km away.  The train commute from the train station at nearby Richlands - 30 min.

I mean, really:  do people from Sydney know how cheaply they can buy in Brisbane compared to Sydney?

Maybe the Queensland government and Brisbane City Council should run advertisements down there:  "Sure, you might be lowering your expectations, but you'll also be lowering your mortgage by up to 500%."...