Prof Münzel and his colleagues investigated the effect of e-cigarette vapour on blood flow in the brachial artery in the upper arm in 20 healthy smokers before they vaped an e-cigarette and then 15 minutes afterwards. They also measured how stiff the artery became.
They also did a mouse study.
The conclusions:
They found that just one vaping episode increased heart rates and caused the arteries to stiffen and the inner lining of the arteries, the endothelium, to stop working properly in the smokers. The endothelium is responsible for maintaining the correct dilation and constriction of blood vessels, protects tissues from toxic substances and regulates inflammation and blood clotting processes. Endothelial dysfunction is involved in the development of cardiovascular disease.
Prof Münzel said: "The results of the present studies identified several molecular mechanisms whereby e-cigarettes can cause damage to the blood vessels, lungs, heart and brain. This is a consequence of toxic chemicals that are produced by the vaping process and may also be present at lower concentrations in the liquid itself. Importantly, we identified an enzyme, NOX-2, that mediated all the effects of e-cigarettes on the brain and cardiovascular system, and we found that a toxic chemical called acrolein, which is produced when the liquid in e-cigarettes is vaporised, activated the damaging effects of NOX-2. The beneficial effects of macitentan and bepridil indicate that e-cigarettes have the capacity to trigger constriction of blood vessels and to impair our cells' antioxidant and survival systems.
"Our data may indicate that e-cigarettes are not a healthy alternative to traditional cigarettes, and their perceived 'safety' is not warranted. In addition, we still have no experience about the health side effects of e-cigarettes arising from long-term use. The e-cigarette epidemic in the US and Europe, in particular among our youth, is causing a huge generation of nicotine-addicted people who are being endangered by encouragement to switch from traditional cigarettes to e-cigarettes. Research like ours should serve as a warning about their dangers, and aggressive steps should be taken to protect our children from health risks caused by e-cigarettes."
A limitation of the study was that no healthy non-smokers were included. However, the researchers point out that a strength is that they have received no funding from the e-cigarette industry. "Recent studies indicate that e-cigarette industry funding is more likely to lead to results that indicate that e-cigarettes are harmless," write the researchers in their paper.
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