I saw mention of this somewhere else - perhaps on a Youtube video I never linked to? - but there's an article in Science which makes it clear that it is a very serious problem for the prospects of fusion as a viable energy source:
A shortage of tritium fuel may leave fusion energy with an empty tank
Fusion advocates often boast that the fuel for their reactors will be cheap and plentiful. That is certainly true for deuterium: Roughly one in every 5000 hydrogen atoms in the oceans is deuterium, and it sells for about $13 per gram. But tritium, with a half-life of 12.3 years, exists naturally only in trace amounts in the upper atmosphere, the product of cosmic ray bombardment. Nuclear reactors also produce tiny amounts, but few harvest it.
Most fusion scientists shrug off the problem, arguing that future reactors can breed the tritium they need. The high-energy neutrons released in fusion reactions can split lithium into helium and tritium if the reactor wall is lined with the metal. Despite demand for it in electric car batteries, lithium is relatively plentiful.
But there’s a catch: In order to breed tritium you need a working fusion reactor, and there may not be enough tritium to jump-start the first generation of power plants. The world’s only commercial sources are the 19 Canada Deuterium Uranium (CANDU) nuclear reactors, which each produce about 0.5 kilograms a year as a waste product, and half are due to retire this decade. The available tritium stockpile—thought to be about 25 kilograms today—will peak before the end of the decade and begin a steady decline as it is sold off and decays, according to projections in ITER’s 2018 research plan.
The article does mention that there are other fusion fuels theoretically possible, but require something like ten (ok, seven) times the heat to work:
TAE Technologies, a California startup, plans to use plain hydrogen and boron, whereas Washington state startup Helion will fuse deuterium and helium-3, a rare helium isotope. These reactions require higher temperatures than D-T, but the companies think that’s a price worth paying to avoid tritium hassles. “Our company’s existence owes itself to the fact that tritium is scarce and a nuisance,” says TAE CEO Michl Binderbauer.
The alternative fusion reactions have the added appeal of producing fewer or even no neutrons, which avoids the material damage and radioactivity that the D-T approach threatens. Binderbauer says the absence of neutrons should allow TAE’s reactors—which stabilize spinning rings of plasma with particle beams—to last 40 years. The challenge is temperature: Whereas D-T will fuse at 150 million degrees Celsius, hydrogen and boron require 1 billion degrees.
I know it is risky to ever bet against technological advances - but on the other hand, someone in the 1940's who pooh-poohed a science fiction magazine's cover showing flying car highways in the sky in the 21st century would be looking prescient.
Hence, I'm strongly tempted to bet against fusion ever being a viable energy source, in any century.


