Babies and bugs

Babies weak immune systems let good bacteria in 

As any new parent knows, infants are notoriously susceptible to bacterial infections. A study now suggests that the body engineers this vulnerability deliberately, allowing beneficial microbes to colonize the baby’s gut, skin, mouth and lungs. Learning to manipulate this system could lead to treatments for infections in newborns, and perhaps even improve the way babies are vaccinated.

n the womb, a fetus is sterile. But from the moment that a baby travels down the birth canal, bacteria and fungi begin their colonization. How the immune system tolerates this sudden influx of invaders has been a mystery.

I wonder, from where do babies born via caesarian pick up their useful bugs.   Must look around for that information later...

Update:  an answer? -

In vaginally-born babies, the bacteria destined for the gut microbiota originate primarily in the maternal birth canal and rectum. Once these bacteria are swallowed by the newborn, they travel through the stomach and colonize the upper and lower intestine, a complicated process that evolves rapidly.

Infants born by cesarean section—particularly cesareans performed before labor begins—don’t encounter the bacteria of the birth canal and maternal rectum. (If a cesarean is performed during labor the infant may be exposed to these bacteria, but to a lesser degree than in vaginal birth.) Instead, bacteria from the skin and hospital environment quickly populate the bowel. As a result, the bacteria inhabiting the lower intestine following a cesarean birth can differ significantly from those found in the vaginally-born baby.

The wages of sin (or at least, dubious taste)

To dye for? Jury still out on tattoo ink causing cancer

Given that I would be pleased if the entire tattoo industry was banned, and my "anti tattoo league" post continues getting hits and (often) upsets the tattooed of the world, I have been reading the stories about the possible dangers of tattoo ink with interest.  The article above is not sensationalist enough for my purposes, but it gives a reasonable background.

I hear the trip is going well...

Just trying to get an extra click or two...

Longer lives

An extra six months to live: babies can now expect to reach 82 in Australia 

That's nice.

But I was surprised that we are third behind not only Japan (that was expected) but also Hong Kong.

Given that I would say the average diet in Hong Kong contains much more fat than Japan, I am surprised it is up there in the longevity stakes.  Is it because they both eat a lot of fish?

Uh-oh

Risk of massive asteroid strike underestimated 

The asteroid that exploded on 15 February this year near the city of Chelyabinsk in the Urals region of Russia was the largest to crash to Earth since 1908, when an object hit Tunguska in Siberia. Using video recordings of the event, scientists have now reconstructed the asteroid's properties and its trajectory through Earth’s atmosphere. The risk of similar objects hitting our planet may be ten times larger than previously thought, they now warn....

The rock was an ordinary chondrite from the asteroid belt located between the orbits of Mars and Jupiter, as revealed by its trajectory and by its elemental and mineral composition, mainly silicates that formed the Solar System billions of years ago. At the time it entered the atmosphere, its mass was of the order of 12,000–13,000 metric tonnes, report two studies published online today in Nature¹ and another study published at the same time in Science². This is nearly twice as heavy as initial estimates had suggested and also larger than revised estimates published in June.

The asteroid roared through Earth’s upper atmosphere at an initial speed of around 19 kilometres per second — more than 50 times the speed of sound. At an altitude of between 45 and 30 kilometres, the heavily fractured, and hence rather fragile, body broke into pieces and finally burst into gas and dust at around 27 kilometres' altitude.

“Luckily, most of the kinetic energy was absorbed by the atmosphere,” says Jiří Borovička, an asteroid researcher at the Astronomical Institute, part of the Academy of Sciences of the Czech Republic in Ondřejov, near Prague. ”A more solid rock that might have blasted closer to the ground would have caused considerably more damage.”

Where Pope Francis is coming from

This does sound consistent with the way Pope Francis has talked since taking on the top job, and it is very remarkable:

What is the fundamental difference between Judaism and Christianity? Writing for Commentary in 1948, Irving Kristol argued that while Judaism took human experience as its starting point, Christianity began with principles it believed to be eternally true and demanded that human life conform to them. Judaism, he averred, posits “an unbreakable bond between the love of God and the love of all reality” and sanctifies all dimensions of life. Christianity, in contrast, encourages asceticism as a means of transcending our creaturely nature.

Jorge Mario Bergoglio—now better known as Pope Francis—strongly disagrees. In On Heaven and Earth, a series of conversations with Rabbi Abraham Skorka of Argentina translated in April, he asserts that Christianity must understand the needs of humans. He rejects attempts to impose dogmatic principles onto human life, and thinks that the Church must be sensitive, and even sometimes deferential, to cultural change. Indeed, he notes, “religion has a right to give an opinion as long as it is in service to the people.” In so arguing, he presents a vision of Catholicism that is both deeply principled and unabashedly heterodox.   
               
Bergoglio insists that the Church cannot transcend culture. He is unafraid to illustrate how the Church has changed in response to shifting cultural trends, pointing to, for instance, its recent acceptance of divorcees as full members. He takes this point further by suggesting that more changes might be necessary. In an astonishing concession, he opines that the Church’s sensitivity to the course of human events might someday lead it to discard the celibacy requirement for the clergy.

Krugman rubs it in

Paul Krugman has some fun in yet another post about Republicans who refuse to give up on their "dire inflation just around the corner" warnings:

Back to the evidence versus the orthodoxy. I can, in a way, understand refusing to believe in global warming — that’s a noisy process, with lots of local variation, and the overall measures are devised by pointy-headed intellectuals who probably vote Democratic. I can even more easily understand refusing to believe in evolution. But the failure of predicted inflation to materialize is happening in real time, right in front of our eyes; people who kept believing in inflation just around the corner lost a lot of money. Yet the denial remains total.

I guess it’s a matter of who you’re gonna believe — Ayn Rand or your own lying eyes.

Norman explains

What the research says about cholesterol and statins - Health Report

I tend to trust Norman Swan when he summarises where medical science is at, so this article in response to the recent kerfuffle about the Catalyst program seems pretty good to me.

(It certainly seems the first episode of the two parter - neither of which I happened to see - relied on doctors of the shonky salesmen variety.  Why would a normally good show like Catalyst do that?)

They could be right

Nuclear energy needed to head off climate change, scientists say

I still say that there really needs to be a serious look, perhaps by an internal scientific/engineering commission of some sort, at the type of smaller scale, passively safe nuclear reactor designs which could be more rapidly deployed than the enormously expensive large nuclear power plants which take a decade or more to build and forever to decommission.

But I've been saying that for years...

Goal achieved

Health Check: should we aim for daily bowel movements?

This article, by a doctor who seems to have a particular interest in constipation, is most notable for the Bristol Stool Chart.  I am slightly amused at the prospect of being able to assign a particular category to my daily "habit".  

My body seems to have adapted to a daily pattern identical to my father's.  I wonder how other many people find that...

Direct brain stimulation for self improvement coming?

If this story does not end up in Jason Soon's twitter feed, I'll eat my hat.

A fascinating article in the New York Times (Jumper Cables for the Mind) indicates that there has been a lot of study on how mild (very mild) brain stimulation can help improve brain performance.

I have briefly noted such claims before, but I had no idea that it had been the subject of a lot of study.  I thought it was just the odd (possibly crankish) scientist here and there who said it seemed to work well.  But read this:

Fregni and his collaborators at Harvard have published more than 200 papers on tDCS. In 2005, he co-wrote a paper showing that stimulating the left prefrontal cortex while you are doing a particular task can enhance working memory, the ability to track and mentally manipulate multiple objects of attention. He has since tested its effects on migraine, chronic pain, post-stroke paralysis, Parkinson’s disease, depression, tinnitus, fibromyalgia, marijuana craving and, strangely enough, the tendency to lie (or, as the paper more delicately put it, “the modulation of untruthful responses”). 

The evidence, he said, is strongest for depression. Earlier this year he published a study in JAMA Psychiatry involving 120 people suffering from major depression. They received either 2 milligrams per day of the antidepressant Zoloft, 2 milliamps of tDCS, both or a placebo. After six weeks, the mood of those treated with either Zoloft or tDCS alone improved about equally well compared with those in the placebo group. “By itself, tDCS was exactly the same as Zoloft at relieving depression. But when you combine the two, you have a synergistic effect, larger than either alone. That’s how I see the effects of tDCS, enhancing something else.” 

One of the most striking examples of cognitive enhancement comes from research supported by the U.S. Air Force, showing that tDCS improves pilots’ vigilance and target detection. “The military has been looking at how to improve vigilance for the past 50 or 60 years,” said Andy McKinley, a civilian biomedical engineer who has been studying tDCS at the Air Force Research Laboratory at Wright-Patterson Air Force Base in Ohio. “At minimum we get a twofold improvement in how long a person can maintain performance. We’ve never seen that with anything else.”

Why isn't this better known?

Late for Halloween

I'm a few days late for stories which make for some good Halloween reading, but here you go anyway:

*   George Orwell thought he had once seen a ghost in a graveyard.   (Or, at least, thought he had a hallucination which resembled a ghost sighting.)  It wasn't a particularly clear sort of encounter, by the sounds, but it does appear to have puzzled him.

All atheists should have a ghost sighting, I think.  It would be good for their soul.

*  Goblins were not necessarily bad.  A benedictine monk wrote about them in 1746:

Calmet stressed goblins’ helpfulness and lack of malevolence, which meant that they were not devils. They only became dangerous when angered, like Hecdekin. But neither were they angels, their “waggish tricks” lacking dignity. Goblins were somewhere in between.

Brand classified the goblins linguistically. They were the same as Brownies in Scotland, related to fairies, and “a Kind of Ghost”. Brand believed that ‘goblin’ came from ancient Greek, meaning ‘house spirit’, and that hobgoblins were a species known for hopping on one leg. The name ‘Brownies’ referred to their swarthy colour, which came from their hard labour. The origin of the belief itself, Brand suggested, was Persia or Arabia. However, since Samuel Johnson had noted that no one had spoken of Brownies “for many years”, Brand thought they were extinct.

Goblin beliefs were, indeed, changing. Calmet might have dismissed the existence of vampires, but he believed in goblins because of good eyewitness accounts. William Bourne in 1725—and Brand who agreed with him—would have seen this as Calmet’s popish credulity. Goblins only flourished “in the benighted Ages of Popery, when Hobgoblins and Sprights were in every City and Town and Village”. These were stories told around winter fires that added “to the natural Fearfulness of Men, and makes them many times imagine they see Things”. Goblin extinction, then, was a move from superstitious excess (as Bourne and Brand saw it) towards reason. The classification of goblins was a way of putting them in their place.

*  Smithsonian.com has a fascinating, lengthy article on the origins of the ouija board, as well as talking about some of the fascinating modern studies of it from a psychological point of view.  For example, I don't think I had heard of this before:

 Participants were told that they were playing with a person in another room via teleconferencing; the robot, they were told, mimicked the movements of the other person. In actuality, the robot’s movements simply amplified the participants’ motions and the person in the other room was just a ruse, a way to get the participant to think they weren’t in control. Participants were asked a series of yes or no, fact-based questions (“Is Buenos Aires the capital of Brazil? Were the 2000 Olympic Games held in Sydney?”) and expected to use the Ouija board to answer.

What the team found surprised them: When participants were asked, verbally, to guess the answers to the best of their ability, they were right only around 50 percent of the time, a typical result for guessing. But when they answered using the board, believing that the answers were coming from someplace else, they answered correctly upwards of 65 percent of the time. “It was so dramatic how much better they did on these questions than if they answered to the best of their ability that we were like, ‘This is just weird, how could they be that much better?’” recalled Fels. “It was so dramatic we couldn’t believe it.” The implication was, Fels explained, that one’s non-conscious was a lot smarter than anyone knew.

Cool technology, even if it achieves little

I don't really know that anyone really needs a mobile phone or tablet that has the display curving over the edge, but it is a very cool look:

As told by the Liberal Party...

Enders discussed

The movie version of Enders Game has caused so much discussion, partly because of the author's strident and conservative views on homosexuality, partly because Harrison Ford has apparently been acting as grumpy and difficult as ever in interviews, and (possibly) because it is sort of a hard novel to imagine being well filmed.  

I see that the movie has received some reasonable reviews, and some poor ones.

But I liked this article from Salon that, while treating the novel more seriously than I am sure it deserves, does make the point that story is, well, ridiculous, even by the standards of young adult science fiction:

In this respect, “Ender’s Game” is less about the ethics of total warfare than it is about wanting to be a hero and a victim at the same time. Is there anything sillier than the idea that the entire planet would entrust its survival to a 10-year-old boy? Despite Card’s narrative bushwa about them being somehow more adaptable to warfare, children are simply developmentally incapable of exercising the judgment required to command an army. Only a kid would find the idea of one doing so even remotely credible, in the same way that only as a child did I find it thrilling that Aslan let Peter and Edmund Pevensie (about the same age, or younger, than Ender) strap on armor and take up swords to defend Narnia. Even those people who are so depraved as to use child soldiers do so because children can be completely dominated, not because they make good leaders.

I read the novel only a few years ago, and came away completely puzzled as to why it is held in high regard by anyone.    

I thought it was poorly written, with the psychology of the characters poorly developed, sadistic in tone, and the action in the training sequences exceedingly dull. 

The Heinlein juveniles were great literature in comparison.  While Heinlein movies have a poor record of good translation to the screen, I would much rather see some of those stories updated and on the screen instead of this dross.

Seems an odd bit of defence planning...

Navy new destroyer: USS Zumwalt is bigger, badder than any other destroyer ( video) - CSMonitor.com

This sounds odd:

The USS Zumwalt is big: It is 610 feet long, has an 11,000-square foot flight deck, and displaces 14,564 tons of water. That’s about 100 feet longer and 50 times the water displacement of other destroyers, the Military Times reported.

Despite its colossal size, Zumwalt is also stealthy, with concealed antennas and an angular frame that makes it much less detectable to radar than are current warships. It also packs a punch. Its “Advanced Gun System” fires warheads at a range of about 63 miles with impeccable precision, three times farther than current destroyers can fire, CNN reported. Its massive electrical capabilities are also expected to support future laser weapons.

But, as precedent suggests with ships of unprecedented size, there’s a problem: Engineers aren’t quite sure if Zumwalt ships are capable of weathering giant waves, according to Defense News. A single sizable swell that hits the ship’s back end might take the ship down, engineers have said. That’s because these ships sport a new, downward-sloping hull that primes the ship to move stealthily, but not necessarily stably; traditional ships have upward-flaring hulls.

The ships are controversial for more than just their Achilles hull: They are expensive – the most expensive Navy ships ever built, to be exact.

 Not sure that I would want to be on the crew of the first one that gets into very heavy seas.

(The Defence News article in the link is from 2007, so the issue has been discussed for a long time.)

Dark matter is really hard to find

First results from LUX dark matter detector rule out some candidates

It sounds like a big, expensive experiment that may well turn up nothing.  Still, the challenges of finding dark matter are huge:

Though dark matter has not yet been detected directly, scientists are fairly certain that it exists. Without its gravitational influence, galaxies and galaxy clusters would simply fly apart into the vastness of space. But because dark matter does not emit or reflect light, and its interactions with other forms of matter are vanishingly rare, it is exceedingly difficult to spot.

"To give some idea of how small the probability of having a dark matter particle interact, imagine firing one dark matter particle into a block of lead," Gaitskell said. "In order to get a 50-50 chance of the particle interacting with the lead, the block would need to stretch for about 200 light years—this is 50 times farther than the nearest star to the Earth aside from the sun. So it's an incredibly rare interaction."

Capturing those interactions requires an incredibly sensitive detector. The key part of the LUX is a third of a ton of supercooled xenon in a tank festooned with light sensors, each capable of detecting a single photon at a time. When a particle interacts with the xenon, it creates a tiny flash of light and an ion charge, both of which are picked up by the sensors.

To minimize extraneous interactions not due to dark matter, the detector must be shielded from background radiation and cosmic rays. For that reason, the LUX is located 4,850 feet underground, submerged in 71,600 gallons of pure de-ionized water.

But even in that fortress of solitude, occasional background interactions still happen. It's the job of LUX physicists to separate the signal from the noise.

The JFK anniversary

Adam Gopnik: The Assassination of J.F.K., Fifty Years Later : The New Yorker

Quite a good essay by Gopnick.   I liked the last couple of paragraphs in particular, even though I'm not keen on the very last sentence:

Again and again, the investigation discloses bizarre figures and coincidences within a web of incident that seem significant in themselves. The case of Judith Campbell Exner is famous. She really was J.F.K.’s mistress, and a Sinatra girlfriend, and the mistress of the Chicago Mob boss Sam Giancana, all within a few years. Even if she wasn’t actually a go-between from one to the other, that would not alter the reality that she had slept with all three, and so lived in worlds that, in 1963, no one would have quite believed could penetrate each other so easily. Still more startling is the case of the painter Mary Pinchot Meyer, who was also unquestionably one of Kennedy’s mistresses. She was the ex-wife of a high-ranking C.I.A. officer (who himself had once had pacifist leanings), an intimate of Timothy Leary, at Harvard, and an LSD user. She was murdered, in 1964, on the towpath in D.C., in murky circumstances. Even if none of this points toward a larger occult truth—even if her death was just a mugging gone wrong—the existence of such a figure says something about the weave of American experience. Worlds that seemed far apart at the time are now shown to have been close together, unified by men and women of multiple identities, subject to electric coincidences—no one more multiple than J.F.K. himself, the prudent political pragmatist who was also the reckless erotic adventurer, in bed with molls and Marilyns, and maybe even East German spies.

The passion of J.F.K. may lie in the overlay of all those strands and circles. The pattern—weaving and unweaving in front of our eyes, placing unlikely people in near proximity and then removing them again—is its own point. Mailer was right when he claimed that the official life of the country and the real life had come apart, but who could have seen that it would take a single violent act, rather than “existential” accomplishment, to reveal how close they really were? Oswald acted alone, but the hidden country acted through Oswald. This is the perpetual film-noir moral lesson: that the American hierarchy is far more unstable than it seems, and that the small-time crook in his garret and the big-time social leader in his mansion are intimately linked. When Kennedy died, and the mystery of his murder began, we took for granted that the patrician in tails with the perfect family and the sordid Oswald belonged to different worlds, just as Ruby’s Carousel Club and the White House seemed light-years apart. When Kennedy was shot, the dignified hierarchy seemed plausible. Afterward, it no longer did. What turned inside out, after his death, was that reality: the inner surface and the outer show, like a magician’s bag, were revealed to be interchangeable. That’s why the death of J.F.K., even as it fades into history, remains so close, close as can be, and closer than that. ♦

Elves are big in Iceland

Why So Many Icelanders Still Believe in Invisible Elves - Ryan Jacobs - The Atlantic

A few paragraphs of particular interest:

Though Jónsdóttir’s belief in elves may sound extreme, it is fairly common for Icelanders to at least entertain the possibility of their existence. In one 1998 survey, 54.4 percent of Icelanders said they believed in the existence of elves. That poll is fairly consistent with other findings and with qualitative fieldwork, according to an academic paper published in 2000 titled “The Elves’ Point of View" by Valdimar Hafstein, who now is a folkloristics professor at the University of Iceland. “If this was just one crazy lady talking about invisible friends, it's really easy to laugh about that,” Jónsdóttir said. “But to have people through hundreds of years talking about the same things, it’s beyond one or two crazy ladies. It is part of the nation.” ...

The elves differ from the extremely tiny figures that are typically depicted as assistants to Santa Claus in popular American mythology. And unlike the fairies of Britain and other parts of Europe, Icelandic elves live and look very much like humans, according to Simpson and other experts. “You’ve got to get right up close before you can be sure it is an elf and not a human,” said Simpson, who began studying Old Icelandic in her undergraduate days and later compiled a book full of Icelandic legend translations. When elves are spotted, they are typically donning “the costume of a couple of hundred years ago,” when many of the stories really came alive.

 Their behavior is also similar to that of people: “[T]heir economy is of the same sort: like humans, the hidden people have livestock, cut hay, row boats, flense whales and pick berries,” Hafstein writes. “Like humans, they too have priests and sheriffs and go to church on Sundays.” This would explain the elf church in the lava field. According to Jónsdóttir, elves can range wildly in size, from a few centimeters to three meters in height. But Icelanders typically come into contact with the smaller ones: one “around one foot tall” and “the other...is perhaps similar to a 7-year-old child.” They may live in houses, sometimes with multiple floors, and, if you leave them alone, they’ll generally mind their own business. According to Simpson, “treat them with respect, do not upset their dwelling places, or try to steal their cattle, and they’ll be perfectly ... quite neutral, quite harmless.”

The whole article is a great read, actually.  (Including views from the elf skeptics of Iceland.)

I guess this may explain a lot about the peculiarity of Bjork, too....

Two years without trial for "blasphemy"

Saudi 'blasphemy' prisoner Hamza Kashgari tweets for first time after release | GulfNews.com

Don't think I had heard this story before:

A writer and newspaper columnist in the Saudi city of Jeddah, Kashgari in February 2011 tweeted a series of comments reflecting meditatively on the human side of the Prophet, and imagining a meeting between himself and the Prophet.

Religious conservatives in the kingdom called the tweets blasphemous. Clerics — one of whom posted a video on YouTube of himself weeping at the perceived insult to the Prophet — called for Kashgari’s death.

After fleeing Saudi Arabia to escape death threats, Kashgari was arrested in Malaysia. Saudi authorities jailed him for nearly two years without trial.

Yeah, well, good on you Malaysia. [/sarc].

(It's pretty obvious, given his release, that the tweets were not truly blasphemous.)