Silver benefits

Silver makes antibiotics thousands of times more effective 

I mentioned earlier this year that I was trying a new deodorant which claimed to incorporate silver ions.   (The exact quantity of them remains a mystery.)  I am happy to report that it seems to work well.

Silver's useful effect against bacteria other than those that live in my armpit (sorry for that image) are discussed in the above Nature article:

Many antibiotics are thought to kill their targets by producing reactive oxygen compounds, and Collins and his team showed that when boosted with a small amount of silver these drugs could kill between 10 and 1,000 times as many bacteria. The increased membrane permeability also allows more antibiotics to enter the bacterial cells, which may overwhelm the resistance mechanisms that rely on shuttling the drug back out.

That disruption to the cell membrane also increased the effectiveness of vancomycin, a large-molecule antibiotic, on Gram-negative bacteria — which have a protective outer coating. Gram-negative bacterial cells can often be impenetrable to antibiotics made of larger molecules.

“It’s not so much a silver bullet; more a silver spoon to help the Gram-negative bacteria take their medicine,” says Collins.

But too much silver does have toxicity:

Vance Fowler, an infectious-disease physician at Duke University in Durham, North Carolina, says the work is “really cool” but sounds a note of caution about the potential toxicity of silver. “It has had a chequered past,” he says.

In the 1990s, for example, a heart valve made by St. Jude Medical, based in St. Paul, Minnesota, included parts covered with a silver coating called Silzone to fight infection. “It did a fine job of preventing infection,” says Fowler. “The problem was that the silver was also toxic to heart tissue.” As a result the valves often leaked².

Before adding silver to antibiotics, “we’ll have to address the toxicity very carefully”, says Fowler. Ingesting too much silver can also cause argyria, a condition in which the skin turns a blue-grey colour — and the effect is permanent.

That bit about blue-grey skin puts me in mind of alleged UFO aliens.   Possibly, they come from a planet (or future) with too much silver.  (It's a theory....)