Unwanted side effects, noted

Last week, the New York Times ran an article covering what I had said before - that it was very weird/peculiar how the American Right had embraced psychedelic therapy given its history of conservatism on the use of drugs.     

It's not a bad article, but one comment in particular caught my attention:

As usual, the enthusiasm here risks outpacing the evidence. While many benefit from psychedelic therapies, research suggests roughly 3–9% of users experience severe lasting difficulties rather than relief. That’s not a reason to halt research, but it does complicate the “miracle cure” narrative. If these treatments are to be scaled, the tradeoff isn’t just access versus stigma, but benefit versus the real possibility of harm for a minority of patients. At the very least, we need to have resources in place for those who do suffer from extended post-psychedelic difficulties.  

Curious about those figures, I asked an AI service about research on the question of what percentage of people trying psychedelic therapy find they suffer harm instead of improvement.  It referred me to this online article, by a psychologist "working in psychedelic research", who said she was wanted to present a balanced picture.  

She writes:

    In Compass Pathways' clinical research trial investigating psilocybin as a treatment for treatment-resistant depression, approximately 5% of patients experienced treatment-emergent serious adverse events including intentional self-injury and suicidal ideation. The company noted these events "are regularly observed in a treatment-resistant depression patient population," but occurred more often in the 25mg group than in the 10mg or 1mg groups (Compass Pathways, 2021).

    McNamee et al., (2023) cited evidence from trials using MDMA and psilocybin (Goodwin et al., 2022) that shows an increase of suicidal ideation and self-injury in approx. 7% of participants.

(In an earlier section talking about studies of people using it recreationally having much higher reported case of adverse effect on mental health - but I am mainly interested here in the results on those using it in a medically supervised setting.)

So, it does seem to back up that 3 - 9% estimate by the commenter in the NYT.

And this made me think - isn't it ironic that it's the same people in the American Right who went off their brain about the side effects of COVID vaccination who are now all nonchalant about the side effects of psychedelic therapy.

Yet what was the rate of adverse effects from COVID vaccine?   AI, help me again:

A WHO analysis covering more than 732 million doses across the Western Pacific Region found reporting rates of serious adverse events following immunization (AEFIs) at 5.6 per 100,000 doses administered (roughly 56 per million). The reported rates of adverse events of special interest were within the range of expected background rates, and the conclusion was that vaccine benefits far outweigh the risks.

As a percentage:  .0056%. 

And another paper notes these numbers:

Between December 13, 2020, and April 13, 2022, a total of 467,890,599 COVID-19 vaccine doses were administered to individuals aged 5–65 years in the US, of which 180 million people received at least 2 doses. In association with these, a total of 177,679 AEFI were reported to the Vaccine Adverse Event reporting System (VAERS) of which 31,797 (17.9%) were serious.

Now, as everyone should recall, not every single reported adverse effect reported to VAERS is going to genuinely be related to the vaccination, but even if we allow (for the sake of argument) that all 32,000 odd "serious adverse effects" were caused by the vaccine, what percentage of total jabs does it indicate?

31,797/467,890,599 = 0.0000679 x 100 = .00679%

So, close enough to the .0056% figure.

You can see my point now, I presume - it seems that serious side effects from COVID vaccination were about a thousand times less likely than those from psychedelic therapy, yet American Right wingers hypocritically attack one but endorse the other.   They have terrible judgement...